Valentina Daniela SISU, Onda Tabita CALUGARU, Mihaela DRAGOMIR, Silvia APOSTEANU, Daniel CORIU
ET2 gene (4q24) is one of the most important regulatory factors of the methylation process in human genome. The homologous protein is directly involved in conversion of 5-methylcytosine into 5-hydroximethylcytosine (1). Loss of function mutations in TET2 gene are considered to be driver mutations (initiating mutations) for leukemogenesis. In some cases these can be found in early clonal cells of Acute Myeloid Leukemia (AML), Acute Lymphoblastic Leukemia (ALL) or Myelodisplastic Syndromes (MDS) (2). The aim of this study is to determinate the frequency of TET2 mutations in Acute Leukemia (AL) patients.
https://doi.org/10.59854/dhrrh.2023.1.4.185