Stefan-Antoniu AIONESE, Mihaela CIRSTEA, Oana RIZEA, Aurelia TATIC
Introduction: Lymphomas comprise a heterogeneous group of lymphoid malignancies and represent the fourth most common malignancy diagnosed during pregnancy.
Methods: This study explores the diagnostic and therapeutic challenges of diffuse large B-cell lymphoma in the gestational context.
We present the case of a 29-year-old female patient, without comorbidities, diagnosed with non-Hodgkin diffuse large B-cell lymphoma at 24 weeks of gestation. During the antepartum period, she was administered CHOP chemotherapy without rituximab, considering the potential lymphodepleting effects of rituximab and the increased risk of fetal infection. Postpartum treatment included one cycle of R-Hyper-CVAD and four cycles of R-CHOP, resulting in a complete metabolic response on PET-CT (Deauville score 1).
The pregnancy resulted in the delivery of a live preterm infant at 34 weeks via Cesarean section. At the 6-year follow-up, the child exhibits age-appropriate growth and development. The patient remains in complete remission five years post-diagnosis.
Conclusions: The diagnosis and treatment of malignant non-Hodgkin lymphoma during pregnancy represent a challenge, requiring an extensive multidisciplinary approach. Treatment decisions depend heavily on the patient’s medical history and the gestational trimester and need a high standard of therapeutic management.
Keywords: Diffuse large B-cell lymphoma; pregnancy; treatment
https://doi.org/10.59854/dhrrh.2026.4.2.91
Cite this article
Aionese S.-A., Cirstea M., Rizea O., Tatic A., Challenges in the management of DLBCL in Pregnancy – A Case Report. DHRRH, 2026, 6(2), https://doi.org/10.59854/dhrrh.2026.4.2.91
