Sandor-Szilard PORTIK, Laura URIAN, Mihnea ZDRENGHEA, Anca VASILACHE, Tunde TOROK, Andrada PARVU, Ciprian TOMULEASA, Delia DIMA, Ioana RUS, Oana MESAROS, Laura JIMBU, Anca BOJAN
Introduction: Polycythemia vera is a chronic myeloproliferative neoplasm associated with an increased risk of thrombotic events, the main cause of morbidity and mortality. The established risk factors are age ≥60 years and prior thrombosis.
Objectives: To identify clinical, biological and therapeutic factors associated with thrombosis in PV patients.
Materials and Methods: We conducted a retrospective, single-center study of 89 JAK+ PV patients diagnosed and treated between January 2015 and August 2025 in the Hematology Department of the “Prof. Dr. Ion Chiricuță” Institute of Oncology, Cluj-Napoca. Demographic, clinical, treatment-related and laboratory data (erythrocytes, hemoglobin, hematocrit, RDW, leukocytes, platelets, ferritin) were analyzed. Statistical evaluation was performed in GraphPad Prism using t-tests, Chi-square tests and logistic regression.
Results: The median age at diagnosis was 61,3 years; 50,5% were female. Comorbidities were present in 53,9%, most frequently arterial hypertension (47,9%). Thrombosis occurred in 19 patients (21,3%): 7 pre-diagnosis, 11 post-diagnosis and 1 both pre- and post-diagnosis, with an equal arterial/venous distribution. In univariate analysis, patients with thrombosis were older (66,63 vs. 59,91 years; p=0,039) and had higher RDW (53,57 vs. 49,17; p=0,007). Other factors (comorbidities, treatment) were not significantly associated with thrombosis. Multivariate regression identified RDW as the only independent predictor of thrombotic risk (HR=1,7; 95%CI: 1,06–4,2; p<0,005). Age and lower hematocrit showed trends (HR=1,04 and HR=0,62) without statistical significance.
Conclusion: RDW, a simple and affordable hematologic parameter, was independently associated with thrombotic risk in PV and may serve as an additional marker for thrombotic risk stratification.
Keywords: polycythemia vera, thrombotic risk, RDW
https://doi.org/10.59854/dhrrh.2026.4.2.67
Cite this article
Portik S.-S., Urian L., Zdrenghea M., Vasilache A., Torok T. et al., Prognostic Factors in Polycythemia Vera. DHRRH, 2026, 6(2), https://doi.org/10.59854/dhrrh.2026.4.2.67
